This gene encodes a subunit of the tetrameric nuclear activating signal cointegrator 1 (ASC-1) complex, which associates with transcriptional coactivators, nuclear receptors and basal transcription factors to facilitate nuclear receptors-mediated transcription. This protein is localized in the nucleus and contains an E1A-type zinc finger domain, which mediates interaction with transcriptional coactivators and ligand-bound nuclear receptors, such as thyroid hormone receptor and retinoid X receptor alpha, but not glucocorticoid receptor. Mutations in this gene are associated with spinal muscular atrophy with congenital bone fractures-1 (SMABF1). [provided by RefSeq, Apr 2016]
Transcription factors with Perturb-seq knockdown data for TRIP4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRIP4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRIP4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:64,093,386–64,094,387 | 293.9 kb | Distal (>10kb) Multiome | 765 | |
| chr15:64,095,741–64,096,612 | 291.9 kb | Distal (>10kb) Multiome | 839 | |
| chr15:64,146,930–64,147,642 | 240.6 kb | Distal (>10kb) Multiome | 403 | |
| chr15:64,151,111–64,152,828 | 236.2 kb | Distal (>10kb) Multiome HiCAR | 586 | |
| chr15:64,152,948–64,154,154 | 234.1 kb | Distal (>10kb) Multiome HiCAR | 593 | |
| chr15:64,162,530–64,163,834 | 224.6 kb | Distal (>10kb) Multiome HiCAR | 876 | |
| chr15:64,355,477–64,356,649 | 31.6 kb | Distal (>10kb) Multiome | 748 | |
| chr15:64,381,037–64,381,737 | 6.3 kb | Proximal (<10kb) Multiome | 630 | |
| chr15:64,387,554–64,388,126 | 71 bp | At TSS Multiome | 1137 | |
| chr15:64,430,220–64,430,746 | 42.6 kb | Distal (>10kb) Multiome | 350 | |
| chr15:64,460,117–64,462,256 | 74.1 kb | Distal (>10kb) Multiome | 930 | |
| chr15:64,588,906–64,589,753 | 201.5 kb | Distal (>10kb) Multiome | 112 | |
| chr15:64,634,613–64,635,221 | 247.0 kb | Distal (>10kb) Multiome | 309 |
Genomic view of the TRIP4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.