This gene encodes a protein that interacts with thyroid hormone receptors, also known as hormone-dependent transcription factors. The gene product interacts specifically with the ligand binding domain. This gene is one of several that may play a role in early-stage non-small cell lung cancer. [provided by RefSeq, Oct 2009]
Transcription factors with Perturb-seq knockdown data for TRIP13. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRIP13 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRIP13, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:611,543–612,836 | 280.6 kb | Distal (>10kb) Multiome | 508 | |
| chr5:693,160–693,784 | 199.4 kb | Distal (>10kb) Multiome | 258 | |
| chr5:784,104–785,298 | 108.1 kb | Distal (>10kb) Multiome | 316 | |
| chr5:891,199–891,462 | 1.4 kb | Proximal (<10kb) | 231 | |
| chr5:892,342–893,335 | 79 bp | At TSS Multiome | 802 | |
| chr5:1,004,572–1,005,613 | 112.1 kb | Distal (>10kb) Multiome | 404 | |
| chr5:1,008,462–1,009,631 | 115.9 kb | Distal (>10kb) Multiome | 276 | |
| chr5:1,102,030–1,102,780 | 209.5 kb | Distal (>10kb) Multiome | 207 | |
| chr5:1,111,233–1,112,367 | 219.1 kb | Distal (>10kb) Multiome | 516 |
Genomic view of the TRIP13 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.