This gene was identified based on the interaction of its protein product with thyroid hormone receptor beta. This protein is associated with the Golgi apparatus. The N-terminal region of the protein binds Golgi membranes and the C-terminal region binds the minus ends of microtubules; thus, the protein is thought to play a role in assembly and maintenance of the Golgi ribbon structure around the centrosome. Mutations in this gene cause achondrogenesis type IA.[provided by RefSeq, Mar 2010]
Transcription factors with Perturb-seq knockdown data for TRIP11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRIP11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRIP11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:91,835,675–91,837,066 | 203.5 kb | Distal (>10kb) Multiome | 412 | |
| chr14:91,947,236–91,948,135 | 92.3 kb | Distal (>10kb) Multiome | 316 | |
| chr14:92,039,326–92,040,502 | 2 bp | At TSS Multiome | 937 | |
| chr14:92,048,621–92,048,853 | 8.6 kb | Proximal (<10kb) | 3 | |
| chr14:92,105,904–92,107,104 | 66.6 kb | Distal (>10kb) Multiome | 794 | |
| chr14:92,121,241–92,122,514 | 81.8 kb | Distal (>10kb) Multiome | 838 | |
| chr14:92,322,882–92,323,968 | 283.4 kb | Distal (>10kb) Multiome | 231 |
Genomic view of the TRIP11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.