This gene encodes a large protein that functions as a GDP to GTP exchange factor. This protein promotes the reorganization of the actin cytoskeleton, thereby playing a role in cell migration and growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Transcription factors with Perturb-seq knockdown data for TRIO. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRIO upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRIO, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:14,011,046–14,012,023 | 131.6 kb | Distal (>10kb) Multiome | 768 | |
| chr5:14,142,126–14,145,472 | 1.7 kb | Proximal (<10kb) Multiome | 820 | |
| chr5:14,148,886–14,149,189 | 5.5 kb | Proximal (<10kb) | 251 | |
| chr5:14,264,639–14,265,088 | 121.5 kb | Distal (>10kb) Multiome | 549 |
Genomic view of the TRIO locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.