TRIM8

tripartite motif containing 8 | GERP, RNF27

This gene encodes a member of the tripartite motif (TRIM) protein family. Based on similarities to other proteins, the encoded protein is suspected to be an E3 ubiquitin-protein ligase. Regulation of this gene may be altered in some cancers. Mutations resulting in a truncated protein product have been observed in early-onset epileptic encephalopathy (EOEE). [provided by RefSeq, Sep 2016]

Member of: DE-1 DE-1.2

Biological processes 29 terms

PML body (GO:0016605)canonical NF-kappaB signal transduction (GO:0007249)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)host-mediated suppression of symbiont invasion (GO:0046597)identical protein binding (GO:0042802)innate immune response (GO:0045087)innate immune response (GO:0045087)negative regulation of viral transcription (GO:0032897)nuclear body (GO:0016604)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of autophagy (GO:0010508)positive regulation of canonical NF-kappaB signal transduction (GO:0043123)protein K63-linked ubiquitination (GO:0070534)protein binding (GO:0005515)protein homodimerization activity (GO:0042803)protein ubiquitination (GO:0016567)suppression of viral release by host (GO:0044790)suppression of viral release by host (GO:0044790)transcription coactivator activity (GO:0003713)ubiquitin protein ligase activity (GO:0061630)ubiquitin protein ligase activity (GO:0061630)zinc ion binding (GO:0008270)

Expression (TPM)

TFs regulating TRIM8 0 TFs

Transcription factors with Perturb-seq knockdown data for TRIM8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRIM8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to TRIM8

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRIM8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr10:102,393,940–102,396,107	246.8 kb	Distal (>10kb) Multiome	912
chr10:102,399,132–102,400,002	242.9 kb	Distal (>10kb) Multiome	832
chr10:102,408,600–102,409,538	233.4 kb	Distal (>10kb) Multiome	277
chr10:102,410,213–102,410,909	231.7 kb	Distal (>10kb) Multiome	148
chr10:102,418,158–102,422,381	222.9 kb	Distal (>10kb) Multiome	1097
chr10:102,422,562–102,423,126	219.6 kb	Distal (>10kb) Multiome	721
chr10:102,431,859–102,432,863	209.9 kb	Distal (>10kb) Multiome	828
chr10:102,449,444–102,451,250	192.8 kb	Distal (>10kb) Multiome	810
chr10:102,454,792–102,455,588	187.5 kb	Distal (>10kb) Multiome	159
chr10:102,460,805–102,462,064	181.1 kb	Distal (>10kb) Multiome	665
chr10:102,501,628–102,503,235	140.3 kb	Distal (>10kb) Multiome	738
chr10:102,503,432–102,504,897	138.5 kb	Distal (>10kb) Multiome	684
chr10:102,641,824–102,646,130	2.6 kb	Proximal (<10kb) Multiome	1123
chr10:102,678,809–102,679,295	36.5 kb	Distal (>10kb) Multiome	476
chr10:102,713,669–102,715,337	71.9 kb	Distal (>10kb) Multiome	895
chr10:102,743,388–102,744,547	101.3 kb	Distal (>10kb) Multiome	777
chr10:102,776,775–102,777,340	134.5 kb	Distal (>10kb) Multiome	419
chr10:102,853,920–102,854,718	211.9 kb	Distal (>10kb) Multiome	859
chr10:102,869,308–102,870,223	227.1 kb	Distal (>10kb) Multiome	509
chr10:102,916,941–102,919,907	275.7 kb	Distal (>10kb) Multiome	984

Genome Browser

Genomic view of the TRIM8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.