Enables ubiquitin protein ligase activity. Involved in defense response to virus; positive regulation of signal transduction; and protein monoubiquitination. Predicted to be located in cytoplasm. Predicted to be active in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TRIM56. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRIM56 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRIM56, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:100,827,001–100,828,324 | 257.8 kb | Distal (>10kb) Multiome | 794 | |
| chr7:100,835,906–100,837,766 | 248.7 kb | Distal (>10kb) Multiome | 766 | |
| chr7:100,852,057–100,853,190 | 233.0 kb | Distal (>10kb) Multiome | 805 | |
| chr7:100,874,652–100,875,664 | 210.5 kb | Distal (>10kb) Multiome | 1020 | |
| chr7:100,888,882–100,891,520 | 195.7 kb | Distal (>10kb) Multiome | 1077 | |
| chr7:100,894,188–100,896,392 | 189.5 kb | Distal (>10kb) Multiome | 609 | |
| chr7:100,896,481–100,897,567 | 188.4 kb | Distal (>10kb) Multiome | 538 | |
| chr7:101,077,663–101,077,944 | 7.5 kb | Proximal (<10kb) | 412 | |
| chr7:101,085,076–101,085,958 | 17 bp | At TSS Multiome | 732 | |
| chr7:101,153,861–101,155,183 | 69.0 kb | Distal (>10kb) Multiome | 670 | |
| chr7:101,162,599–101,164,796 | 77.6 kb | Distal (>10kb) Multiome | 654 | |
| chr7:101,165,195–101,166,546 | 80.2 kb | Distal (>10kb) Multiome | 980 | |
| chr7:101,173,985–101,174,835 | 88.7 kb | Distal (>10kb) Multiome | 323 | |
| chr7:101,216,957–101,218,626 | 132.3 kb | Distal (>10kb) Multiome | 918 | |
| chr7:101,232,007–101,233,160 | 147.0 kb | Distal (>10kb) Multiome | 304 | |
| chr7:101,244,041–101,245,521 | 159.5 kb | Distal (>10kb) Multiome | 989 | |
| chr7:101,251,898–101,252,786 | 166.9 kb | Distal (>10kb) Multiome | 751 | |
| chr7:101,282,845–101,283,297 | 197.6 kb | Distal (>10kb) Multiome | 300 | |
| chr7:101,294,017–101,295,035 | 208.8 kb | Distal (>10kb) Multiome | 188 | |
| chr7:101,299,826–101,300,551 | 214.6 kb | Distal (>10kb) Multiome | 147 | |
| chr7:101,302,606–101,303,724 | 217.4 kb | Distal (>10kb) Multiome | 167 | |
| chr7:101,308,000–101,309,265 | 222.9 kb | Distal (>10kb) Multiome | 357 | |
| chr7:101,321,440–101,322,377 | 236.4 kb | Distal (>10kb) Multiome | 537 | |
| chr7:101,362,703–101,363,475 | 277.4 kb | Distal (>10kb) Multiome | 258 | |
| chr7:101,363,545–101,364,217 | 278.6 kb | Distal (>10kb) Multiome | 584 |
Genomic view of the TRIM56 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.