TRIM46

tripartite motif containing 46 | FLJ23229, TRIFIC

This gene encodes a protein of the tripartite motif (TRIM) family. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. TRIM46 is reported to be involved in the proliferation of multiple types of cancer cells including lung and breast cancer. It has also been shown to control neuronal polarity and axon specification by forming uniform microtubule bundles in the axon. [provided by RefSeq, May 2022]

Biological processes 17 terms

anterograde synaptic vesicle transport (GO:0048490)axon (GO:0030424)axon cytoplasm (GO:1904115)axon initial segment (GO:0043194)axonogenesis (GO:0007409)cytoskeleton (GO:0005856)main axon (GO:0044304)main axon (GO:0044304)main axon (GO:0044304)microtubule bundle formation (GO:0001578)negative regulation of axon extension (GO:0030517)neuron migration (GO:0001764)positive regulation of anterograde dense core granule transport (GO:1901953)proximal neuron projection (GO:1990769)regulation of protein localization (GO:0032880)regulation of protein localization (GO:0032880)zinc ion binding (GO:0008270)

Expression (TPM)

TFs regulating TRIM46 0 TFs

Transcription factors with Perturb-seq knockdown data for TRIM46. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRIM46 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to TRIM46

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRIM46, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:154,936,148–154,937,752	236.8 kb	Distal (>10kb) Multiome	1149
chr1:154,955,571–154,956,925	217.6 kb	Distal (>10kb) Multiome	504
chr1:154,961,269–154,962,529	212.0 kb	Distal (>10kb) Multiome	985
chr1:154,970,161–154,971,641	202.8 kb	Distal (>10kb) Multiome	535
chr1:154,972,362–154,975,914	199.2 kb	Distal (>10kb) Multiome	1085
chr1:154,982,968–154,983,632	190.6 kb	Distal (>10kb) Multiome	693
chr1:154,998,961–155,004,423	174.4 kb	Distal (>10kb) Multiome	1210
chr1:155,017,084–155,017,941	156.3 kb	Distal (>10kb) Multiome	1003
chr1:155,050,292–155,052,078	122.6 kb	Distal (>10kb) Multiome	948
chr1:155,061,415–155,064,552	112.1 kb	Distal (>10kb) Multiome HiCAR	860
chr1:155,070,748–155,071,423	102.7 kb	Distal (>10kb) Multiome	542
chr1:155,078,524–155,079,535	94.9 kb	Distal (>10kb) Multiome	397
chr1:155,079,852–155,081,529	92.8 kb	Distal (>10kb) Multiome HiCAR	539
chr1:155,084,373–155,086,501	88.8 kb	Distal (>10kb) Multiome HiCAR	865
chr1:155,091,315–155,091,900	82.2 kb	Distal (>10kb) Multiome HiCAR	594
chr1:155,126,247–155,126,903	47.4 kb	Distal (>10kb) Multiome HiCAR	776
chr1:155,127,607–155,128,120	46.0 kb	Distal (>10kb) Multiome HiCAR	578
chr1:155,135,100–155,136,750	38.0 kb	Distal (>10kb) Multiome	938
chr1:155,166,847–155,168,170	6.0 kb	Proximal (<10kb) Multiome	622
chr1:155,172,629–155,174,979	722 bp	At TSS Multiome	903
chr1:155,176,698–155,176,895	2.9 kb	Proximal (<10kb)	236
chr1:155,192,921–155,194,099	19.8 kb	Distal (>10kb) Multiome	755
chr1:155,194,230–155,195,403	21.1 kb	Distal (>10kb) Multiome	753
chr1:155,196,127–155,196,592	22.6 kb	Distal (>10kb) Multiome	97
chr1:155,207,822–155,209,789	35.2 kb	Distal (>10kb) Multiome	826
chr1:155,227,312–155,228,116	53.9 kb	Distal (>10kb) Multiome	688
chr1:155,244,103–155,245,349	71.0 kb	Distal (>10kb) Multiome	900
chr1:155,250,356–155,251,199	77.0 kb	Distal (>10kb) Multiome	605
chr1:155,255,032–155,255,921	81.7 kb	Distal (>10kb) Multiome	661
chr1:155,261,679–155,262,788	88.6 kb	Distal (>10kb) Multiome	921
chr1:155,272,928–155,274,098	99.7 kb	Distal (>10kb) Multiome	768
chr1:155,276,933–155,278,884	103.5 kb	Distal (>10kb) Multiome	749
chr1:155,308,291–155,309,348	135.0 kb	Distal (>10kb) Multiome	934
chr1:155,320,564–155,321,470	147.1 kb	Distal (>10kb) Multiome	341
chr1:155,322,680–155,325,643	150.6 kb	Distal (>10kb) Multiome	979

Genome Browser

Genomic view of the TRIM46 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.