This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, namely a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TRIM44. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRIM44 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRIM44, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:35,402,638–35,403,312 | 259.8 kb | Distal (>10kb) Multiome | 55 | |
| chr11:35,418,192–35,419,975 | 243.4 kb | Distal (>10kb) Multiome | 384 | |
| chr11:35,525,471–35,526,213 | 136.9 kb | Distal (>10kb) Multiome | 283 | |
| chr11:35,617,628–35,620,590 | 44.5 kb | Distal (>10kb) Multiome | 755 | |
| chr11:35,662,341–35,663,428 | 115 bp | At TSS Multiome | 1145 | |
| chr11:35,821,506–35,822,608 | 159.3 kb | Distal (>10kb) Multiome | 433 | |
| chr11:35,943,672–35,944,947 | 281.4 kb | Distal (>10kb) Multiome | 502 |
Genomic view of the TRIM44 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.