The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Although the function of the protein is unknown, the RING domain suggests that the protein may have DNA-binding activity. The gene localizes to the major histocompatibility complex (MHC) class I region on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2011]
Transcription factors with Perturb-seq knockdown data for TRIM26. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRIM26 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRIM26, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:29,926,526–29,927,449 | 286.3 kb | Distal (>10kb) Multiome | 372 | |
| chr6:30,006,934–30,007,571 | 206.2 kb | Distal (>10kb) Multiome | 195 | |
| chr6:30,060,737–30,061,999 | 152.1 kb | Distal (>10kb) Multiome | 973 | |
| chr6:30,066,588–30,067,716 | 146.3 kb | Distal (>10kb) Multiome | 952 | |
| chr6:30,101,800–30,102,573 | 111.3 kb | Distal (>10kb) Multiome | 644 | |
| chr6:30,103,094–30,103,626 | 110.0 kb | Distal (>10kb) Multiome | 616 | |
| chr6:30,171,597–30,172,574 | 41.4 kb | Distal (>10kb) Multiome | 185 | |
| chr6:30,207,044–30,207,811 | 6.0 kb | Proximal (<10kb) Multiome | 514 | |
| chr6:30,212,953–30,213,888 | 58 bp | At TSS Multiome | 826 | |
| chr6:30,213,977–30,214,728 | 1.2 kb | Proximal (<10kb) Multiome | 758 | |
| chr6:30,259,131–30,260,199 | 46.1 kb | Distal (>10kb) Multiome | 475 | |
| chr6:30,325,606–30,327,611 | 113.6 kb | Distal (>10kb) Multiome | 1043 | |
| chr6:30,344,843–30,345,715 | 131.8 kb | Distal (>10kb) Multiome | 892 | |
| chr6:30,357,696–30,358,238 | 144.5 kb | Distal (>10kb) Multiome | 207 | |
| chr6:30,466,230–30,466,713 | 253.1 kb | Distal (>10kb) Multiome | 369 | |
| chr6:30,489,117–30,490,512 | 276.9 kb | Distal (>10kb) Multiome | 750 |
Genomic view of the TRIM26 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.