The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies and its function has not been determined. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Transcription factors with Perturb-seq knockdown data for TRIM14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRIM14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRIM14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:97,922,022–97,923,085 | 196.8 kb | Distal (>10kb) Multiome | 1110 | |
| chr9:97,982,380–97,985,451 | 134.5 kb | Distal (>10kb) Multiome | 994 | |
| chr9:98,056,283–98,057,271 | 62.5 kb | Distal (>10kb) Multiome | 868 | |
| chr9:98,087,291–98,088,183 | 31.5 kb | Distal (>10kb) Multiome | 281 | |
| chr9:98,118,693–98,119,508 | 34 bp | At TSS Multiome | 752 | |
| chr9:98,191,695–98,193,531 | 73.8 kb | Distal (>10kb) Multiome | 795 | |
| chr9:98,218,786–98,219,246 | 99.8 kb | Distal (>10kb) Multiome | 178 | |
| chr9:98,255,174–98,256,530 | 136.6 kb | Distal (>10kb) Multiome | 905 | |
| chr9:98,315,414–98,316,053 | 196.5 kb | Distal (>10kb) Multiome | 373 |
Genomic view of the TRIM14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.