TRIB1
tribbles pseudokinase 1 | C8FW, GIG2, TRB1

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; mitogen-activated protein kinase kinase binding activity; and protein kinase inhibitor activity. Involved in several processes, including JNK cascade; negative regulation of lipopolysaccharide-mediated signaling pathway; and regulation of protein kinase activity. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2025]

Member of: DE-4 Developmental clusters: GC7
Biological processes 39 terms
ATP binding (GO:0005524)RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629)RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629)cytoplasm (GO:0005737)cytosol (GO:0005829)enzyme binding (GO:0019899)enzyme regulator activity (GO:0030234)mitogen-activated protein kinase kinase binding (GO:0031434)mitogen-activated protein kinase kinase binding (GO:0031434)negative regulation of JNK cascade (GO:0046329)negative regulation of MAPK cascade (GO:0043409)negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)negative regulation of neutrophil differentiation (GO:0045659)negative regulation of smooth muscle cell migration (GO:0014912)negative regulation of smooth muscle cell proliferation (GO:0048662)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of eosinophil differentiation (GO:0045645)positive regulation of macrophage differentiation (GO:0045651)positive regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032436)positive regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032436)positive regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032436)protein binding (GO:0005515)protein kinase activity (GO:0004672)protein kinase binding (GO:0019901)protein kinase inhibitor activity (GO:0004860)regulation of MAP kinase activity (GO:0043405)regulation of protein metabolic process (GO:0051246)response to lipopolysaccharide (GO:0032496)response to lipopolysaccharide (GO:0032496)response to lipopolysaccharide (GO:0032496)transcription regulator inhibitor activity (GO:0140416)transcription regulator inhibitor activity (GO:0140416)ubiquitin protein ligase binding (GO:0031625)ubiquitin protein ligase binding (GO:0031625)ubiquitin-protein transferase regulator activity (GO:0055106)ubiquitin-protein transferase regulator activity (GO:0055106)
Expression (TPM)
TRIB1 — as a Regulated Gene

TFs regulating TRIB1 0 TFs

Transcription factors with Perturb-seq knockdown data for TRIB1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRIB1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to TRIB1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRIB1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr8:125,091,367–125,092,149 338.6 kb Distal (>10kb) Multiome HiCAR 874
chr8:125,333,917–125,334,658 95.9 kb Distal (>10kb) Multiome 599
chr8:125,386,297–125,387,506 43.4 kb Distal (>10kb) Multiome 453
chr8:125,388,382–125,388,991 41.7 kb Distal (>10kb) Multiome 153
chr8:125,426,891–125,427,596 2.8 kb Proximal (<10kb) 355
chr8:125,429,082–125,432,504 312 bp At TSS Multiome 1185
chr8:125,434,646–125,435,080 4.3 kb Proximal (<10kb) 566
chr8:125,540,867–125,541,751 110.9 kb Distal (>10kb) Multiome HiCAR 267
chr8:125,548,995–125,549,682 118.9 kb Distal (>10kb) Multiome HiCAR 19
chr8:125,590,170–125,591,900 160.6 kb Distal (>10kb) Multiome 187

Genome Browser

Genomic view of the TRIB1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr8:125,081,367 – 125,601,900
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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