Predicted to be involved in T cell receptor signaling pathway; adaptive immune response; and alpha-beta T cell activation. Located in plasma membrane. Part of alpha-beta T cell receptor complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TRBC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRBC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRBC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:142,696,147–142,697,139 | 104.2 kb | Distal (>10kb) Multiome | 120 | |
| chr7:142,782,876–142,783,641 | 17.7 kb | Distal (>10kb) Multiome | 448 | |
| chr7:142,795,483–142,795,907 | 5.1 kb | Proximal (<10kb) | 132 | |
| chr7:142,796,189–142,798,065 | 3.0 kb | Proximal (<10kb) | 224 | |
| chr7:142,813,144–142,813,828 | 12.4 kb | Distal (>10kb) Multiome | 250 | |
| chr7:142,853,711–142,856,176 | 53.1 kb | Distal (>10kb) Multiome | 583 | |
| chr7:142,885,313–142,886,162 | 84.8 kb | Distal (>10kb) Multiome | 160 |
Genomic view of the TRBC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.