Predicted to enable GABA receptor binding activity and myosin binding activity. Involved in endosome to lysosome transport. Located in early endosome and mitochondrion. Implicated in developmental and epileptic encephalopathy 68. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TRAK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRAK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRAK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:40,524,355–40,525,405 | 1635.3 kb | Distal (>10kb) Multiome HiCAR | 904 | |
| chr3:41,961,164–41,962,778 | 198.0 kb | Distal (>10kb) Multiome | 829 | |
| chr3:42,012,939–42,014,361 | 146.6 kb | Distal (>10kb) Multiome | 723 | |
| chr3:42,023,321–42,024,092 | 136.6 kb | Distal (>10kb) Multiome | 142 | |
| chr3:42,025,591–42,026,077 | 134.5 kb | Distal (>10kb) Multiome | 400 | |
| chr3:42,042,809–42,043,844 | 116.8 kb | Distal (>10kb) Multiome | 435 | |
| chr3:42,159,717–42,160,505 | 163 bp | At TSS Multiome | 491 | |
| chr3:42,164,040–42,164,701 | 3.8 kb | Proximal (<10kb) | 61 | |
| chr3:42,264,672–42,265,502 | 104.8 kb | Distal (>10kb) Multiome | 182 | |
| chr3:42,270,524–42,271,571 | 110.7 kb | Distal (>10kb) Multiome | 132 | |
| chr3:42,349,668–42,350,325 | 189.7 kb | Distal (>10kb) Multiome | 246 | |
| chr3:42,446,025–42,446,484 | 286.1 kb | Distal (>10kb) Multiome | 27 |
Genomic view of the TRAK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.