Tumor necrosis factor (TNF; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF receptor superfamily (see MIM 191190). TRAFs are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs; a coiled-coil (leucine zipper) motif; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in self-association and receptor binding.[supplied by OMIM, Apr 2004]
Transcription factors with Perturb-seq knockdown data for TRAF7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRAF7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRAF7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:1,918,171–1,918,773 | 237.3 kb | Distal (>10kb) Multiome | 129 | |
| chr16:1,929,283–1,930,271 | 226.0 kb | Distal (>10kb) Multiome | 780 | |
| chr16:1,942,671–1,943,761 | 212.4 kb | Distal (>10kb) Multiome | 750 | |
| chr16:1,958,923–1,960,140 | 196.3 kb | Distal (>10kb) Multiome | 826 | |
| chr16:1,964,300–1,965,434 | 190.9 kb | Distal (>10kb) Multiome | 933 | |
| chr16:1,971,481–1,972,435 | 183.8 kb | Distal (>10kb) Multiome | 1010 | |
| chr16:1,979,111–1,980,324 | 176.4 kb | Distal (>10kb) Multiome | 296 | |
| chr16:1,983,450–1,984,851 | 171.8 kb | Distal (>10kb) Multiome | 917 | |
| chr16:1,989,307–1,993,568 | 163.4 kb | Distal (>10kb) Multiome | 706 | |
| chr16:2,003,882–2,004,348 | 151.7 kb | Distal (>10kb) Multiome | 619 | |
| chr16:2,009,742–2,010,504 | 145.9 kb | Distal (>10kb) Multiome | 752 | |
| chr16:2,022,700–2,023,923 | 132.5 kb | Distal (>10kb) Multiome | 682 | |
| chr16:2,026,629–2,027,149 | 128.9 kb | Distal (>10kb) Multiome | 249 | |
| chr16:2,047,366–2,048,252 | 107.9 kb | Distal (>10kb) Multiome | 875 | |
| chr16:2,090,476–2,092,232 | 64.5 kb | Distal (>10kb) Multiome | 344 | |
| chr16:2,135,536–2,136,505 | 19.6 kb | Distal (>10kb) Multiome | 263 | |
| chr16:2,147,864–2,149,260 | 7.3 kb | Proximal (<10kb) Multiome | 679 | |
| chr16:2,149,550–2,152,180 | 4.7 kb | Proximal (<10kb) Multiome | 618 | |
| chr16:2,152,861–2,153,999 | 2.1 kb | Proximal (<10kb) Multiome | 734 | |
| chr16:2,154,834–2,156,329 | 219 bp | At TSS Multiome | 932 | |
| chr16:2,178,140–2,179,722 | 23.0 kb | Distal (>10kb) Multiome | 318 | |
| chr16:2,205,129–2,206,297 | 49.8 kb | Distal (>10kb) Multiome | 887 | |
| chr16:2,214,212–2,215,803 | 59.2 kb | Distal (>10kb) Multiome | 953 | |
| chr16:2,223,095–2,224,285 | 67.7 kb | Distal (>10kb) Multiome | 918 | |
| chr16:2,251,044–2,252,460 | 95.9 kb | Distal (>10kb) Multiome | 996 | |
| chr16:2,267,625–2,269,111 | 112.5 kb | Distal (>10kb) Multiome | 1044 | |
| chr16:2,339,631–2,342,283 | 185.1 kb | Distal (>10kb) Multiome | 1129 | |
| chr16:2,428,282–2,429,948 | 273.5 kb | Distal (>10kb) Multiome | 827 |
Genomic view of the TRAF7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.