TRAF2
TNF receptor associated factor 2 | RNF117, TRAP3

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined. [provided by RefSeq, Jul 2008]

Member of: DE-6 Developmental clusters: GC1
Biological processes 110 terms
CD27 signaling pathway (GO:0160162)CD40 receptor binding (GO:0005174)CD40 receptor binding (GO:0005174)CD40 receptor complex (GO:0035631)CD40 receptor complex (GO:0035631)CD40 signaling pathway (GO:0023035)IRE1-TRAF2-ASK1 complex (GO:1990604)IRE1-TRAF2-ASK1 complex (GO:1990604)IRE1-TRAF2-ASK1 complex (GO:1990604)T cell activation (GO:0042110)TORC1 complex assembly (GO:1905669)TORC1 complex assembly (GO:1905669)TORC2 complex disassembly (GO:1905670)TORC2 complex disassembly (GO:1905670)TRAF2-GSTP1 complex (GO:0097057)cell cortex (GO:0005938)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasmic side of plasma membrane (GO:0009898)cytoplasmic side of plasma membrane (GO:0009898)cytoplasmic side of plasma membrane (GO:0009898)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)enzyme binding (GO:0019899)enzyme binding (GO:0019899)extrinsic apoptotic signaling pathway via death domain receptors (GO:0008625)identical protein binding (GO:0042802)identical protein binding (GO:0042802)inflammatory response (GO:0006954)interleukin-17-mediated signaling pathway (GO:0097400)intrinsic apoptotic signaling pathway in response to DNA damage (GO:0008630)intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)mRNA stabilization (GO:0048255)membrane raft (GO:0045121)metal ion binding (GO:0046872)mitogen-activated protein kinase kinase kinase binding (GO:0031435)negative regulation of glial cell apoptotic process (GO:0034351)non-canonical NF-kappaB signal transduction (GO:0038061)nucleoplasm (GO:0005654)plasma membrane (GO:0005886)positive regulation of JUN kinase activity (GO:0043507)positive regulation of T cell cytokine production (GO:0002726)positive regulation of canonical NF-kappaB signal transduction (GO:0043123)positive regulation of canonical NF-kappaB signal transduction (GO:0043123)positive regulation of canonical NF-kappaB signal transduction (GO:0043123)positive regulation of canonical NF-kappaB signal transduction (GO:0043123)positive regulation of canonical NF-kappaB signal transduction (GO:0043123)positive regulation of extrinsic apoptotic signaling pathway (GO:2001238)positive regulation of gene expression (GO:0010628)positive regulation of interleukin-2 production (GO:0032743)positive regulation of pyroptotic inflammatory response (GO:0140639)positive regulation of tumor necrosis factor-mediated signaling pathway (GO:1903265)programmed cell death (GO:0012501)protein K63-linked ubiquitination (GO:0070534)protein K63-linked ubiquitination (GO:0070534)protein autoubiquitination (GO:0051865)protein autoubiquitination (GO:0051865)protein binding (GO:0005515)protein kinase binding (GO:0019901)protein kinase binding (GO:0019901)protein phosphatase binding (GO:0019903)protein ubiquitination (GO:0016567)protein-containing complex (GO:0032991)protein-containing complex assembly (GO:0065003)protein-containing complex assembly (GO:0065003)protein-containing complex assembly (GO:0065003)protein-containing complex binding (GO:0044877)protein-macromolecule adaptor activity (GO:0030674)protein-macromolecule adaptor activity (GO:0030674)protein-macromolecule adaptor activity (GO:0030674)regulation of JNK cascade (GO:0046328)regulation of MAPK cascade (GO:0043408)regulation of apoptotic process (GO:0042981)regulation of apoptotic process (GO:0042981)regulation of production of molecular mediator of immune response (GO:0002700)regulation of protein-containing complex assembly (GO:0043254)response to endoplasmic reticulum stress (GO:0034976)signal transduction (GO:0007165)signal transduction (GO:0007165)signaling adaptor activity (GO:0035591)signaling adaptor activity (GO:0035591)signaling receptor complex (GO:0043235)sphingolipid binding (GO:0046625)thioesterase binding (GO:0031996)toll-like receptor signaling pathway (GO:0002224)tumor necrosis factor binding (GO:0043120)tumor necrosis factor receptor binding (GO:0005164)tumor necrosis factor receptor binding (GO:0005164)tumor necrosis factor receptor binding (GO:0005164)tumor necrosis factor receptor superfamily binding (GO:0032813)tumor necrosis factor receptor superfamily complex (GO:0002947)tumor necrosis factor-mediated signaling pathway (GO:0033209)tumor necrosis factor-mediated signaling pathway (GO:0033209)tumor necrosis factor-mediated signaling pathway (GO:0033209)tumor necrosis factor-mediated signaling pathway (GO:0033209)tumor necrosis factor-mediated signaling pathway (GO:0033209)ubiquitin ligase complex (GO:0000151)ubiquitin protein ligase activity (GO:0061630)ubiquitin protein ligase activity (GO:0061630)ubiquitin protein ligase binding (GO:0031625)ubiquitin protein ligase binding (GO:0031625)ubiquitin-protein transferase activity (GO:0004842)ubiquitin-protein transferase activity (GO:0004842)ubiquitin-protein transferase activity (GO:0004842)ubiquitin-protein transferase activity (GO:0004842)vesicle membrane (GO:0012506)zinc ion binding (GO:0008270)
Expression (TPM)
TRAF2 — as a Regulated Gene

TFs regulating TRAF2 0 TFs

Transcription factors with Perturb-seq knockdown data for TRAF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRAF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to TRAF2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRAF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr9:136,587,135–136,588,835 298.2 kb Distal (>10kb) Multiome 453
chr9:136,626,479–136,627,366 259.6 kb Distal (>10kb) Multiome 451
chr9:136,665,223–136,666,507 220.7 kb Distal (>10kb) Multiome 409
chr9:136,686,875–136,688,079 199.0 kb Distal (>10kb) Multiome 610
chr9:136,711,795–136,713,743 174.1 kb Distal (>10kb) Multiome 459
chr9:136,727,616–136,729,079 158.3 kb Distal (>10kb) Multiome 1013
chr9:136,762,846–136,763,902 123.3 kb Distal (>10kb) Multiome 271
chr9:136,788,889–136,789,680 97.2 kb Distal (>10kb) Multiome 351
chr9:136,790,433–136,792,285 95.4 kb Distal (>10kb) Multiome 864
chr9:136,798,823–136,801,421 85.2 kb Distal (>10kb) Multiome 874
chr9:136,807,251–136,808,764 78.6 kb Distal (>10kb) Multiome 714
chr9:136,842,325–136,842,872 44.0 kb Distal (>10kb) Multiome 492
chr9:136,846,187–136,850,214 37.1 kb Distal (>10kb) Multiome 1074
chr9:136,865,842–136,866,772 20.1 kb Distal (>10kb) Multiome 742
chr9:136,885,976–136,887,547 107 bp At TSS Multiome 770
chr9:136,943,250–136,945,621 58.2 kb Distal (>10kb) Multiome 883
chr9:136,949,631–136,950,846 63.7 kb Distal (>10kb) Multiome 776
chr9:136,977,106–136,980,430 92.0 kb Distal (>10kb) Multiome 413
chr9:136,991,827–136,993,248 105.8 kb Distal (>10kb) Multiome 720
chr9:137,027,536–137,029,054 141.7 kb Distal (>10kb) Multiome 539
chr9:137,029,231–137,029,652 143.1 kb Distal (>10kb) Multiome 386
chr9:137,045,334–137,046,838 160.0 kb Distal (>10kb) Multiome 829
chr9:137,053,352–137,054,892 167.6 kb Distal (>10kb) Multiome 544
chr9:137,067,810–137,068,494 181.6 kb Distal (>10kb) Multiome 492
chr9:137,069,879–137,071,138 184.1 kb Distal (>10kb) Multiome 703
chr9:137,076,758–137,078,723 190.9 kb Distal (>10kb) Multiome 530
chr9:137,085,844–137,087,716 200.4 kb Distal (>10kb) Multiome 890
chr9:137,129,244–137,130,499 243.3 kb Distal (>10kb) Multiome 823
chr9:137,167,984–137,170,155 283.0 kb Distal (>10kb) Multiome 560

Genome Browser

Genomic view of the TRAF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr9:136,577,135 – 137,180,155
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
Huangfu Lab · Publications · Resources · Contact