Predicted to enable calmodulin binding activity and identical protein binding activity. Predicted to be involved in presynaptic modulation of chemical synaptic transmission; regulation of glutamatergic synaptic transmission; and regulation of synaptic vesicle exocytosis. Predicted to act upstream of or within calcineurin-NFAT signaling cascade; negative regulation of synaptic transmission; and synaptic vesicle docking. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TPRG1L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TPRG1L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TPRG1L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:2,525,908–2,527,142 | 1098.5 kb | Distal (>10kb) Multiome HiCAR | 668 | |
| chr1:2,529,108–2,529,820 | 1095.7 kb | Distal (>10kb) Multiome HiCAR | 222 | |
| chr1:3,453,034–3,455,700 | 171.7 kb | Distal (>10kb) Multiome HiCAR | 874 | |
| chr1:3,471,270–3,471,995 | 153.4 kb | Distal (>10kb) Multiome | 575 | |
| chr1:3,491,285–3,491,949 | 133.5 kb | Distal (>10kb) Multiome | 309 | |
| chr1:3,530,504–3,532,073 | 93.6 kb | Distal (>10kb) Multiome HiCAR | 442 | |
| chr1:3,610,667–3,612,281 | 13.4 kb | Distal (>10kb) Multiome | 361 | |
| chr1:3,619,073–3,619,301 | 5.7 kb | Proximal (<10kb) | 315 | |
| chr1:3,624,289–3,625,883 | 127 bp | At TSS Multiome | 814 | |
| chr1:3,649,785–3,650,304 | 25.1 kb | Distal (>10kb) Multiome | 620 | |
| chr1:3,651,921–3,653,136 | 27.8 kb | Distal (>10kb) Multiome | 369 | |
| chr1:3,746,744–3,747,607 | 122.4 kb | Distal (>10kb) Multiome | 523 | |
| chr1:3,771,515–3,773,363 | 147.6 kb | Distal (>10kb) Multiome | 733 | |
| chr1:3,793,373–3,793,897 | 168.7 kb | Distal (>10kb) Multiome | 182 | |
| chr1:3,795,866–3,796,907 | 171.5 kb | Distal (>10kb) Multiome | 835 | |
| chr1:3,856,527–3,858,218 | 232.3 kb | Distal (>10kb) Multiome | 815 | |
| chr1:3,899,608–3,901,755 | 276.4 kb | Distal (>10kb) Multiome | 1026 | |
| chr1:3,910,694–3,911,367 | 286.0 kb | Distal (>10kb) Multiome | 321 |
Genomic view of the TPRG1L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.