Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TPRG1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TPRG1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TPRG1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:187,737,384–187,742,012 | 1207.1 kb | Distal (>10kb) Multiome HiCAR | 974 | |
| chr3:187,744,634–187,746,096 | 1201.6 kb | Distal (>10kb) Multiome HiCAR | 917 | |
| chr3:187,750,052–187,750,795 | 1196.8 kb | Distal (>10kb) Multiome HiCAR | 613 | |
| chr3:187,989,510–187,990,198 | 957.3 kb | Distal (>10kb) Multiome HiCAR | 260 | |
| chr3:188,049,203–188,050,110 | 897.5 kb | Distal (>10kb) Multiome HiCAR | 67 | |
| chr3:188,152,533–188,155,009 | 793.2 kb | Distal (>10kb) Multiome HiCAR | 878 | |
| chr3:188,947,146–188,948,983 | 615 bp | At TSS Multiome | 630 | |
| chr3:188,954,461–188,954,912 | 7.2 kb | Proximal (<10kb) | 315 | |
| chr3:188,956,908–188,957,117 | 9.7 kb | Proximal (<10kb) | 94 |
Genomic view of the TPRG1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.