This gene encodes a member of the tumor protein D52-like family. These proteins are characterized by an N-terminal coiled-coil motif that is used to form homo- and heteromeric complexes with other tumor protein D52-like proteins. Expression of this gene may be a marker for breast cancer and acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 12. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for TPD52L2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TPD52L2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TPD52L2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:63,573,969–63,574,596 | 291.0 kb | Distal (>10kb) Multiome | 551 | |
| chr20:63,626,480–63,627,647 | 238.3 kb | Distal (>10kb) Multiome | 982 | |
| chr20:63,641,266–63,642,913 | 223.2 kb | Distal (>10kb) Multiome | 691 | |
| chr20:63,652,233–63,654,166 | 211.7 kb | Distal (>10kb) Multiome | 1011 | |
| chr20:63,657,813–63,658,939 | 206.8 kb | Distal (>10kb) Multiome | 1055 | |
| chr20:63,696,254–63,697,070 | 168.7 kb | Distal (>10kb) Multiome | 458 | |
| chr20:63,707,489–63,708,488 | 157.3 kb | Distal (>10kb) Multiome | 1008 | |
| chr20:63,737,573–63,741,470 | 125.6 kb | Distal (>10kb) Multiome | 1098 | |
| chr20:63,775,216–63,775,997 | 89.8 kb | Distal (>10kb) Multiome | 257 | |
| chr20:63,830,341–63,832,721 | 34.0 kb | Distal (>10kb) Multiome | 628 | |
| chr20:63,846,273–63,846,790 | 18.8 kb | Distal (>10kb) Multiome | 487 | |
| chr20:63,864,234–63,865,991 | 162 bp | At TSS Multiome | 1158 | |
| chr20:63,894,341–63,895,764 | 29.7 kb | Distal (>10kb) Multiome | 791 | |
| chr20:63,938,191–63,939,815 | 73.4 kb | Distal (>10kb) Multiome | 287 | |
| chr20:63,939,918–63,942,008 | 76.3 kb | Distal (>10kb) Multiome | 496 | |
| chr20:63,955,375–63,956,875 | 91.1 kb | Distal (>10kb) Multiome | 1107 | |
| chr20:63,956,976–63,958,127 | 92.4 kb | Distal (>10kb) Multiome | 709 | |
| chr20:63,969,149–63,970,667 | 104.7 kb | Distal (>10kb) Multiome | 764 | |
| chr20:63,973,660–63,974,150 | 108.7 kb | Distal (>10kb) Multiome | 767 | |
| chr20:63,980,541–63,981,488 | 115.9 kb | Distal (>10kb) Multiome | 986 | |
| chr20:64,030,226–64,031,221 | 165.5 kb | Distal (>10kb) Multiome | 159 | |
| chr20:64,038,338–64,039,469 | 173.8 kb | Distal (>10kb) Multiome | 628 | |
| chr20:64,047,989–64,049,987 | 184.2 kb | Distal (>10kb) Multiome | 541 | |
| chr20:64,053,902–64,054,682 | 189.0 kb | Distal (>10kb) Multiome | 609 | |
| chr20:64,057,481–64,058,099 | 192.6 kb | Distal (>10kb) Multiome | 659 | |
| chr20:64,062,561–64,063,881 | 197.8 kb | Distal (>10kb) Multiome | 991 | |
| chr20:64,079,311–64,080,472 | 214.6 kb | Distal (>10kb) Multiome | 688 | |
| chr20:64,083,392–64,084,408 | 218.4 kb | Distal (>10kb) Multiome | 591 | |
| chr20:64,101,897–64,102,924 | 237.0 kb | Distal (>10kb) Multiome | 457 | |
| chr20:64,160,199–64,160,889 | 295.2 kb | Distal (>10kb) Multiome | 55 |
Genomic view of the TPD52L2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.