TOX4

TOX high mobility group box family member 4 | LCP1, C14orf92, KIAA0737

Predicted to enable chromatin DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in chromatin and chromosome, telomeric region. Part of PTW/PP1 phosphatase complex. [provided by Alliance of Genome Resources, Apr 2025]

Member of: DE-1 DE-1.3

Biological processes 11 terms

PTW/PP1 phosphatase complex (GO:0072357)RNA polymerase II promoter clearance (GO:0001111)chromatin (GO:0000785)chromatin DNA binding (GO:0031490)chromosome (GO:0005694)chromosome, telomeric region (GO:0000781)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of transcription elongation by RNA polymerase II (GO:0032968)protein binding (GO:0005515)regulation of transcription by RNA polymerase II (GO:0006357)

Expression (TPM)

TFs regulating TOX4 0 TFs

Transcription factors with Perturb-seq knockdown data for TOX4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TOX4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to TOX4

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TOX4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr14:21,191,911–21,192,845	285.1 kb	Distal (>10kb) Multiome	463
chr14:21,268,822–21,270,154	207.6 kb	Distal (>10kb) Multiome	1029
chr14:21,308,204–21,309,328	168.4 kb	Distal (>10kb) Multiome	647
chr14:21,383,896–21,384,850	93.0 kb	Distal (>10kb) Multiome	931
chr14:21,436,834–21,437,890	39.9 kb	Distal (>10kb) Multiome	875
chr14:21,455,683–21,456,683	21.0 kb	Distal (>10kb) Multiome	862
chr14:21,476,573–21,477,687	251 bp	At TSS Multiome	931
chr14:21,510,804–21,511,761	34.1 kb	Distal (>10kb) Multiome	972
chr14:21,525,630–21,527,355	49.2 kb	Distal (>10kb) Multiome	627
chr14:21,534,439–21,535,312	57.6 kb	Distal (>10kb) Multiome	146
chr14:21,536,256–21,537,359	59.7 kb	Distal (>10kb) Multiome	181
chr14:21,557,417–21,557,905	80.4 kb	Distal (>10kb) Multiome	526

Genome Browser

Genomic view of the TOX4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.