This gene encodes a nuclear protein which is serine and arginine rich, and contains a RING-type zinc finger domain. It is highly expressed in the testis, and functions as an ubiquitin-protein E3 ligase. Mutations in this gene are associated with retinitis pigmentosa type 31. Alternatively spliced transcript variants, encoding different isoforms, have been observed for this locus. [provided by RefSeq, Sep 2010]
Transcription factors with Perturb-seq knockdown data for TOPORS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TOPORS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TOPORS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:32,344,322–32,345,899 | 207.9 kb | Distal (>10kb) Multiome | 320 | |
| chr9:32,383,941–32,385,359 | 168.0 kb | Distal (>10kb) Multiome HiCAR | 770 | |
| chr9:32,524,630–32,526,749 | 27.5 kb | Distal (>10kb) Multiome | 802 | |
| chr9:32,550,146–32,552,913 | 1.6 kb | Proximal (<10kb) Multiome | 1007 | |
| chr9:32,553,175–32,553,449 | 589 bp | At TSS | 65 | |
| chr9:32,572,342–32,573,474 | 20.6 kb | Distal (>10kb) Multiome | 817 | |
| chr9:32,782,490–32,784,047 | 230.9 kb | Distal (>10kb) Multiome | 305 | |
| chr9:33,000,845–33,002,021 | 449.0 kb | Distal (>10kb) Multiome HiCAR | 802 |
Genomic view of the TOPORS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.