This gene encodes an import receptor of the outer mitochondrial membrane that is part of the translocase of the outer membrane complex. This protein is involved in the import of mitochondrial precursor proteins. The protein interacts with the SARS-CoV and SARS-Cov-2 ORF9b proteins. [provided by RefSeq, Dec 2021]
Transcription factors with Perturb-seq knockdown data for TOMM70. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TOMM70 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TOMM70, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:100,260,138–100,261,732 | 140.2 kb | Distal (>10kb) Multiome | 908 | |
| chr3:100,334,205–100,335,290 | 66.4 kb | Distal (>10kb) Multiome | 849 | |
| chr3:100,400,431–100,402,077 | 239 bp | At TSS Multiome | 977 | |
| chr3:100,403,404–100,403,783 | 2.3 kb | Proximal (<10kb) | 113 | |
| chr3:100,491,845–100,493,045 | 91.4 kb | Distal (>10kb) Multiome | 816 | |
| chr3:100,601,812–100,603,934 | 201.3 kb | Distal (>10kb) Multiome | 474 |
Genomic view of the TOMM70 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.