Predicted to be involved in protein insertion into mitochondrial outer membrane. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TOMM6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TOMM6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TOMM6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:41,504,922–41,505,512 | 282.3 kb | Distal (>10kb) Multiome | 231 | |
| chr6:41,545,684–41,547,717 | 241.4 kb | Distal (>10kb) Multiome | 837 | |
| chr6:41,560,291–41,561,295 | 226.9 kb | Distal (>10kb) Multiome | 321 | |
| chr6:41,577,904–41,579,491 | 209.0 kb | Distal (>10kb) Multiome | 740 | |
| chr6:41,638,107–41,639,488 | 149.2 kb | Distal (>10kb) Multiome | 240 | |
| chr6:41,683,281–41,684,037 | 103.9 kb | Distal (>10kb) Multiome | 492 | |
| chr6:41,733,652–41,736,107 | 53.4 kb | Distal (>10kb) Multiome | 908 | |
| chr6:41,779,509–41,781,116 | 7.6 kb | Proximal (<10kb) Multiome | 857 | |
| chr6:41,786,100–41,787,779 | 1.1 kb | Proximal (<10kb) Multiome | 1106 | |
| chr6:41,894,347–41,896,221 | 107.7 kb | Distal (>10kb) Multiome | 822 | |
| chr6:41,920,834–41,921,901 | 133.6 kb | Distal (>10kb) Multiome HiCAR | 955 | |
| chr6:41,939,116–41,939,782 | 151.8 kb | Distal (>10kb) Multiome | 401 | |
| chr6:41,940,689–41,942,238 | 154.2 kb | Distal (>10kb) Multiome | 798 | |
| chr6:41,965,433–41,966,075 | 178.1 kb | Distal (>10kb) Multiome | 152 | |
| chr6:42,030,637–42,031,169 | 243.3 kb | Distal (>10kb) Multiome HiCAR | 297 | |
| chr6:42,048,292–42,049,051 | 261.0 kb | Distal (>10kb) Multiome HiCAR | 627 | |
| chr6:42,050,080–42,050,921 | 262.9 kb | Distal (>10kb) Multiome HiCAR | 912 |
Genomic view of the TOMM6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.