The protein encoded by this gene is involved in the import of precursor proteins into mitochondria. The encoded protein has a chaperone-like activity, binding the mature portion of unfolded proteins and aiding their import into mitochondria. This protein, which is found in the cytoplasm and sometimes associated with the outer mitochondrial membrane, has a weak ATPase activity and contains 6 TPR repeats. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TOMM34. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TOMM34 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TOMM34, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:44,745,652–44,746,316 | 214.5 kb | Distal (>10kb) Multiome | 321 | |
| chr20:44,810,403–44,810,885 | 149.8 kb | Distal (>10kb) Multiome | 181 | |
| chr20:44,884,968–44,886,235 | 74.8 kb | Distal (>10kb) Multiome | 913 | |
| chr20:44,909,510–44,910,396 | 50.4 kb | Distal (>10kb) Multiome | 810 | |
| chr20:44,911,292–44,911,995 | 48.7 kb | Distal (>10kb) Multiome | 532 | |
| chr20:44,960,068–44,960,912 | 120 bp | At TSS Multiome | 1025 | |
| chr20:44,966,035–44,967,090 | 6.1 kb | Proximal (<10kb) Multiome | 1001 | |
| chr20:45,098,253–45,098,840 | 138.2 kb | Distal (>10kb) Multiome | 171 |
Genomic view of the TOMM34 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.