This gene encodes a ubiquitin-binding protein that interacts with several Toll-like receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Transcription factors with Perturb-seq knockdown data for TOLLIP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TOLLIP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TOLLIP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:1,262,536–1,263,097 | 46.9 kb | Distal (>10kb) Multiome | 577 | |
| chr11:1,308,732–1,310,441 | 63 bp | At TSS Multiome | 890 | |
| chr11:1,336,825–1,337,928 | 27.2 kb | Distal (>10kb) Multiome | 223 | |
| chr11:1,382,728–1,383,562 | 73.5 kb | Distal (>10kb) Multiome HiCAR | 442 | |
| chr11:1,388,152–1,391,242 | 80.1 kb | Distal (>10kb) Multiome HiCAR | 551 | |
| chr11:1,546,495–1,547,275 | 237.1 kb | Distal (>10kb) Multiome | 395 | |
| chr11:1,568,160–1,568,834 | 258.9 kb | Distal (>10kb) Multiome | 58 | |
| chr11:1,571,981–1,572,819 | 262.7 kb | Distal (>10kb) Multiome | 410 | |
| chr11:1,573,992–1,574,943 | 265.1 kb | Distal (>10kb) Multiome | 379 |
Genomic view of the TOLLIP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.