The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TNS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TNS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TNS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:52,879,361–52,880,433 | 167.1 kb | Distal (>10kb) Multiome | 702 | |
| chr12:52,884,158–52,885,336 | 162.1 kb | Distal (>10kb) Multiome | 610 | |
| chr12:52,903,331–52,905,680 | 143.3 kb | Distal (>10kb) Multiome | 985 | |
| chr12:52,906,476–52,907,649 | 139.7 kb | Distal (>10kb) Multiome | 424 | |
| chr12:52,948,516–52,950,156 | 98.0 kb | Distal (>10kb) Multiome | 923 | |
| chr12:53,005,438–53,007,356 | 40.7 kb | Distal (>10kb) Multiome HiCAR | 995 | |
| chr12:53,046,385–53,049,295 | 444 bp | At TSS Multiome HiCAR | 793 | |
| chr12:53,049,465–53,050,530 | 3.0 kb | Proximal (<10kb) Multiome HiCAR | 565 | |
| chr12:53,053,508–53,054,860 | 7.5 kb | Proximal (<10kb) Multiome HiCAR | 646 | |
| chr12:53,078,790–53,079,991 | 32.4 kb | Distal (>10kb) Multiome HiCAR | 835 | |
| chr12:53,174,900–53,175,484 | 128.3 kb | Distal (>10kb) Multiome | 474 | |
| chr12:53,179,987–53,181,456 | 133.8 kb | Distal (>10kb) Multiome HiCAR | 930 | |
| chr12:53,219,787–53,222,151 | 174.1 kb | Distal (>10kb) Multiome | 828 | |
| chr12:53,231,703–53,233,098 | 185.4 kb | Distal (>10kb) Multiome | 464 | |
| chr12:53,251,461–53,252,566 | 205.1 kb | Distal (>10kb) Multiome | 825 | |
| chr12:53,268,046–53,268,600 | 221.3 kb | Distal (>10kb) Multiome | 709 | |
| chr12:53,295,142–53,295,823 | 248.5 kb | Distal (>10kb) Multiome | 706 | |
| chr12:53,299,515–53,300,187 | 252.8 kb | Distal (>10kb) Multiome | 849 | |
| chr12:53,321,051–53,322,029 | 274.5 kb | Distal (>10kb) Multiome | 935 | |
| chr12:53,324,682–53,326,037 | 278.0 kb | Distal (>10kb) Multiome | 840 | |
| chr12:53,344,427–53,345,660 | 298.0 kb | Distal (>10kb) Multiome | 645 |
Genomic view of the TNS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.