The protein encoded by this gene is a nuclear import receptor for serine/arginine-rich (SR) proteins such as the splicing factors SFRS1 and SFRS2. The encoded protein has also been shown to be involved in HIV-1 infection, apparently through interaction with the HIV-1 capsid protein. Several protein-coding and non-coding transcript variants have been found for this gene. [provided by RefSeq, Apr 2020]
Transcription factors with Perturb-seq knockdown data for TNPO3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TNPO3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TNPO3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:128,782,847–128,783,828 | 271.7 kb | Distal (>10kb) Multiome | 559 | |
| chr7:128,790,457–128,792,157 | 263.8 kb | Distal (>10kb) Multiome | 579 | |
| chr7:128,831,024–128,832,923 | 222.5 kb | Distal (>10kb) Multiome | 529 | |
| chr7:128,842,024–128,842,470 | 212.9 kb | Distal (>10kb) Multiome | 308 | |
| chr7:128,862,244–128,863,913 | 192.3 kb | Distal (>10kb) Multiome | 736 | |
| chr7:128,868,986–128,870,326 | 185.5 kb | Distal (>10kb) Multiome | 557 | |
| chr7:128,879,898–128,880,508 | 174.9 kb | Distal (>10kb) Multiome | 323 | |
| chr7:128,890,731–128,891,934 | 163.8 kb | Distal (>10kb) Multiome | 231 | |
| chr7:128,911,320–128,912,136 | 143.4 kb | Distal (>10kb) Multiome | 216 | |
| chr7:128,937,568–128,938,346 | 117.1 kb | Distal (>10kb) Multiome | 392 | |
| chr7:129,054,212–129,055,537 | 92 bp | At TSS Multiome | 1049 | |
| chr7:129,144,393–129,145,068 | 89.6 kb | Distal (>10kb) Multiome | 477 | |
| chr7:129,168,405–129,170,130 | 114.2 kb | Distal (>10kb) Multiome | 302 | |
| chr7:129,188,088–129,189,694 | 133.5 kb | Distal (>10kb) Multiome | 603 | |
| chr7:129,224,228–129,225,767 | 169.7 kb | Distal (>10kb) Multiome | 899 |
Genomic view of the TNPO3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.