Enables ankyrin repeat binding activity; enzyme binding activity; and protein serine/threonine kinase activator activity. Involved in cellular response to ionizing radiation and double-strand break repair. Located in several cellular components, including adherens junction; heterochromatin; and nucleus. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TNKS1BP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TNKS1BP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TNKS1BP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:57,212,992–57,214,202 | 111.4 kb | Distal (>10kb) Multiome | 248 | |
| chr11:57,236,823–57,238,006 | 87.5 kb | Distal (>10kb) Multiome | 256 | |
| chr11:57,242,064–57,242,828 | 82.5 kb | Distal (>10kb) Multiome | 232 | |
| chr11:57,277,829–57,278,561 | 46.9 kb | Distal (>10kb) Multiome | 338 | |
| chr11:57,310,924–57,312,111 | 13.4 kb | Distal (>10kb) Multiome | 620 | |
| chr11:57,322,352–57,322,979 | 2.0 kb | Proximal (<10kb) | 354 | |
| chr11:57,323,847–57,325,914 | 18 bp | At TSS Multiome | 790 | |
| chr11:57,335,065–57,336,267 | 10.8 kb | Distal (>10kb) Multiome | 689 | |
| chr11:57,345,508–57,346,149 | 20.9 kb | Distal (>10kb) Multiome | 241 | |
| chr11:57,349,624–57,350,269 | 25.0 kb | Distal (>10kb) Multiome | 357 | |
| chr11:57,426,113–57,427,448 | 102.1 kb | Distal (>10kb) Multiome | 451 | |
| chr11:57,457,029–57,457,825 | 132.5 kb | Distal (>10kb) Multiome | 458 | |
| chr11:57,460,127–57,461,576 | 135.6 kb | Distal (>10kb) Multiome | 418 | |
| chr11:57,480,236–57,481,014 | 155.6 kb | Distal (>10kb) Multiome | 300 | |
| chr11:57,482,336–57,483,518 | 158.2 kb | Distal (>10kb) Multiome | 338 | |
| chr11:57,493,430–57,494,126 | 168.7 kb | Distal (>10kb) Multiome | 521 | |
| chr11:57,499,261–57,500,331 | 174.8 kb | Distal (>10kb) Multiome | 548 | |
| chr11:57,514,003–57,516,118 | 189.5 kb | Distal (>10kb) Multiome | 833 | |
| chr11:57,530,326–57,531,572 | 206.0 kb | Distal (>10kb) Multiome | 824 | |
| chr11:57,567,377–57,568,664 | 243.2 kb | Distal (>10kb) Multiome | 665 | |
| chr11:57,597,419–57,598,821 | 273.1 kb | Distal (>10kb) Multiome | 359 |
Genomic view of the TNKS1BP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.