This gene encodes an A20-binding protein which plays a role in autoimmunity and tissue homeostasis through the regulation of nuclear factor kappa-B activation. Mutations in this gene have been associated with psoriatic arthritis, rheumatoid arthritis, and systemic lupus erythematosus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Transcription factors with Perturb-seq knockdown data for TNIP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TNIP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TNIP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:150,783,348–150,783,999 | 297.4 kb | Distal (>10kb) Multiome | 435 | |
| chr5:150,801,105–150,801,901 | 279.6 kb | Distal (>10kb) Multiome | 382 | |
| chr5:151,002,371–151,003,402 | 78.2 kb | Distal (>10kb) Multiome | 132 | |
| chr5:151,020,249–151,021,200 | 60.5 kb | Distal (>10kb) Multiome | 522 | |
| chr5:151,080,524–151,081,640 | 65 bp | At TSS Multiome | 916 | |
| chr5:151,082,297–151,082,500 | 1.2 kb | Proximal (<10kb) | 118 | |
| chr5:151,157,085–151,158,664 | 76.7 kb | Distal (>10kb) Multiome | 760 | |
| chr5:151,223,077–151,224,282 | 142.9 kb | Distal (>10kb) Multiome | 662 | |
| chr5:151,252,199–151,253,942 | 171.9 kb | Distal (>10kb) Multiome | 746 | |
| chr5:151,348,447–151,349,638 | 267.9 kb | Distal (>10kb) Multiome | 138 |
Genomic view of the TNIP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.