The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TNFRSF8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TNFRSF8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TNFRSF8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:11,784,926–11,785,439 | 278.1 kb | Distal (>10kb) Multiome | 531 | |
| chr1:11,802,827–11,804,002 | 259.7 kb | Distal (>10kb) Multiome | 507 | |
| chr1:11,805,133–11,806,702 | 257.2 kb | Distal (>10kb) Multiome | 1034 | |
| chr1:11,907,175–11,910,389 | 153.6 kb | Distal (>10kb) Multiome | 1299 | |
| chr1:11,925,969–11,926,788 | 136.8 kb | Distal (>10kb) Multiome | 632 | |
| chr1:11,934,261–11,935,008 | 128.6 kb | Distal (>10kb) Multiome | 809 | |
| chr1:11,979,601–11,980,894 | 83.0 kb | Distal (>10kb) Multiome | 932 | |
| chr1:12,019,010–12,020,110 | 43.9 kb | Distal (>10kb) Multiome | 841 | |
| chr1:12,067,600–12,068,080 | 4.6 kb | Proximal (<10kb) Multiome | 128 | |
| chr1:12,078,792–12,079,863 | 16.2 kb | Distal (>10kb) Multiome | 281 | |
| chr1:12,166,812–12,167,546 | 103.7 kb | Distal (>10kb) Multiome | 414 | |
| chr1:12,208,729–12,209,345 | 145.7 kb | Distal (>10kb) Multiome | 331 | |
| chr1:12,229,625–12,230,345 | 166.7 kb | Distal (>10kb) Multiome | 666 |
Genomic view of the TNFRSF8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.