This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, one transmembrane domain and a C-terminal ER-retention sequence. This protein is enriched on the mitochondria-associated-membrane of the ER via palmitoylation of two of its cytosolically exposed cysteines. [provided by RefSeq, Jan 2017]
Transcription factors with Perturb-seq knockdown data for TMX2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMX2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMX2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:57,426,113–57,427,448 | 285.5 kb | Distal (>10kb) Multiome | 451 | |
| chr11:57,457,029–57,457,825 | 255.1 kb | Distal (>10kb) Multiome | 458 | |
| chr11:57,460,127–57,461,576 | 252.0 kb | Distal (>10kb) Multiome | 418 | |
| chr11:57,480,236–57,481,014 | 232.1 kb | Distal (>10kb) Multiome | 300 | |
| chr11:57,482,336–57,483,518 | 229.4 kb | Distal (>10kb) Multiome | 338 | |
| chr11:57,493,430–57,494,126 | 218.9 kb | Distal (>10kb) Multiome | 521 | |
| chr11:57,499,261–57,500,331 | 212.8 kb | Distal (>10kb) Multiome | 548 | |
| chr11:57,514,003–57,516,118 | 198.1 kb | Distal (>10kb) Multiome | 833 | |
| chr11:57,530,326–57,531,572 | 181.7 kb | Distal (>10kb) Multiome | 824 | |
| chr11:57,567,377–57,568,664 | 144.5 kb | Distal (>10kb) Multiome | 665 | |
| chr11:57,597,419–57,598,821 | 114.5 kb | Distal (>10kb) Multiome | 359 | |
| chr11:57,637,508–57,640,656 | 74.4 kb | Distal (>10kb) Multiome | 699 | |
| chr11:57,644,541–57,645,304 | 67.6 kb | Distal (>10kb) Multiome | 237 | |
| chr11:57,646,682–57,652,802 | 62.7 kb | Distal (>10kb) Multiome | 580 | |
| chr11:57,656,843–57,658,231 | 55.0 kb | Distal (>10kb) Multiome | 827 | |
| chr11:57,666,634–57,668,805 | 44.8 kb | Distal (>10kb) Multiome | 958 | |
| chr11:57,711,417–57,713,054 | 323 bp | At TSS Multiome | 857 | |
| chr11:57,740,872–57,742,140 | 28.8 kb | Distal (>10kb) Multiome | 973 | |
| chr11:57,761,276–57,762,144 | 49.2 kb | Distal (>10kb) Multiome | 612 | |
| chr11:57,778,066–57,779,000 | 66.1 kb | Distal (>10kb) Multiome | 688 | |
| chr11:57,780,962–57,781,951 | 69.1 kb | Distal (>10kb) Multiome | 317 | |
| chr11:57,800,273–57,801,159 | 88.2 kb | Distal (>10kb) Multiome | 547 | |
| chr11:57,902,618–57,904,039 | 190.7 kb | Distal (>10kb) Multiome | 362 |
Genomic view of the TMX2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.