This gene lies within the male specific region of chromosome Y. Its homolog on chromosome X escapes X inactivation and encodes an actin sequestering protein. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TMSB4Y. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMSB4Y upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMSB4Y, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrY:13,479,167–13,480,489 | 223.8 kb | Distal (>10kb) Multiome | 196 | |
| chrY:13,702,737–13,704,606 | at TSS | At TSS | 274 | |
| chrY:13,751,168–13,752,131 | 47.6 kb | Distal (>10kb) Multiome | 159 | |
| chrY:13,804,123–13,804,943 | 100.7 kb | Distal (>10kb) Multiome | 73 |
Genomic view of the TMSB4Y locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.