This gene encodes a neuronal-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2008]
Transcription factors with Perturb-seq knockdown data for TMOD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMOD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMOD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:51,621,891–51,623,295 | 128.9 kb | Distal (>10kb) Multiome | 786 | |
| chr15:51,681,155–51,681,883 | 70.1 kb | Distal (>10kb) Multiome | 662 | |
| chr15:51,726,326–51,726,848 | 25.1 kb | Distal (>10kb) Multiome | 334 | |
| chr15:51,736,980–51,738,047 | 14.1 kb | Distal (>10kb) Multiome | 521 | |
| chr15:51,751,070–51,752,267 | 85 bp | At TSS Multiome | 433 | |
| chr15:51,829,316–51,830,426 | 78.2 kb | Distal (>10kb) Multiome | 787 | |
| chr15:51,971,175–51,972,397 | 220.2 kb | Distal (>10kb) Multiome | 887 | |
| chr15:52,018,740–52,020,253 | 267.7 kb | Distal (>10kb) Multiome | 1045 |
Genomic view of the TMOD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.