This gene likely encodes a mitochondrial membrane protein. The encoded protein may play a role in biogenesis of mitochondrial ATP synthase. Mutations in this gene have been associated with neonatal mitochondrial encephalocardiomyopathy due to ATP synthase deficiency. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]
Transcription factors with Perturb-seq knockdown data for TMEM70. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM70 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM70, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:73,745,665–73,747,641 | 229.2 kb | Distal (>10kb) Multiome | 863 | |
| chr8:73,877,680–73,879,555 | 97.3 kb | Distal (>10kb) Multiome | 897 | |
| chr8:73,971,155–73,973,036 | 3.9 kb | Proximal (<10kb) Multiome | 889 | |
| chr8:73,975,889–73,976,754 | 23 bp | At TSS Multiome | 855 | |
| chr8:73,985,003–73,985,350 | 8.8 kb | Proximal (<10kb) | 127 | |
| chr8:74,108,336–74,109,315 | 132.5 kb | Distal (>10kb) Multiome | 221 | |
| chr8:74,115,763–74,116,601 | 140.0 kb | Distal (>10kb) Multiome | 93 | |
| chr8:74,163,711–74,164,253 | 187.8 kb | Distal (>10kb) Multiome | 63 | |
| chr8:74,320,238–74,322,101 | 344.4 kb | Distal (>10kb) Multiome HiCAR | 590 |
Genomic view of the TMEM70 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.