Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM42. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM42 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM42, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:44,584,465–44,585,362 | 277.0 kb | Distal (>10kb) Multiome | 388 | |
| chr3:44,624,770–44,625,563 | 236.8 kb | Distal (>10kb) Multiome | 686 | |
| chr3:44,648,515–44,649,232 | 213.2 kb | Distal (>10kb) Multiome | 554 | |
| chr3:44,729,240–44,729,901 | 132.3 kb | Distal (>10kb) Multiome | 780 | |
| chr3:44,761,326–44,762,300 | 100.1 kb | Distal (>10kb) Multiome | 966 | |
| chr3:44,861,375–44,862,600 | 94 bp | At TSS Multiome | 765 | |
| chr3:44,975,358–44,976,703 | 114.3 kb | Distal (>10kb) Multiome | 732 | |
| chr3:45,023,446–45,024,275 | 161.9 kb | Distal (>10kb) Multiome | 117 | |
| chr3:45,145,719–45,146,718 | 284.4 kb | Distal (>10kb) Multiome | 356 |
Genomic view of the TMEM42 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.