Predicted to enable calcium channel activity and voltage-gated monoatomic ion channel activity. Predicted to be involved in calcium ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of monoatomic ion channel complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM37. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM37 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM37, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:119,155,495–119,157,277 | 275.9 kb | Distal (>10kb) Multiome | 202 | |
| chr2:119,223,024–119,224,452 | 208.1 kb | Distal (>10kb) Multiome | 761 | |
| chr2:119,366,351–119,367,938 | 64.9 kb | Distal (>10kb) Multiome | 994 | |
| chr2:119,431,298–119,432,803 | 129 bp | At TSS Multiome | 903 | |
| chr2:119,476,117–119,476,795 | 44.6 kb | Distal (>10kb) Multiome | 482 | |
| chr2:119,523,786–119,524,663 | 92.4 kb | Distal (>10kb) Multiome | 187 | |
| chr2:119,544,074–119,545,082 | 112.6 kb | Distal (>10kb) Multiome | 610 | |
| chr2:119,678,779–119,679,506 | 247.3 kb | Distal (>10kb) Multiome | 786 | |
| chr2:119,700,871–119,701,304 | 269.3 kb | Distal (>10kb) Multiome | 92 | |
| chr2:119,702,889–119,703,364 | 271.2 kb | Distal (>10kb) Multiome | 436 |
Genomic view of the TMEM37 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.