Enables acetylcholine receptor regulator activity. Involved in chaperone-mediated protein complex assembly and positive regulation of protein localization to cell surface. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM35A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM35A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM35A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:100,819,952–100,820,670 | 258.6 kb | Distal (>10kb) Multiome | 553 | |
| chrX:100,928,599–100,929,634 | 149.7 kb | Distal (>10kb) Multiome | 309 | |
| chrX:101,051,311–101,052,275 | 27.0 kb | Distal (>10kb) Multiome | 546 | |
| chrX:101,097,632–101,098,463 | 19.2 kb | Distal (>10kb) Multiome | 508 | |
| chrX:101,348,449–101,349,149 | 270.0 kb | Distal (>10kb) Multiome | 567 |
Genomic view of the TMEM35A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.