Enables aminophospholipid flippase activity. Involved in aminophospholipid transport and positive regulation of protein exit from endoplasmic reticulum. Located in plasma membrane. Part of phospholipid-translocating ATPase complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM30B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM30B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM30B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:60,331,221–60,332,142 | 949.8 kb | Distal (>10kb) Multiome HiCAR | 515 | |
| chr14:60,637,200–60,638,337 | 643.6 kb | Distal (>10kb) Multiome HiCAR | 201 | |
| chr14:60,641,851–60,643,218 | 639.0 kb | Distal (>10kb) Multiome HiCAR | 222 | |
| chr14:60,648,454–60,651,189 | 630.6 kb | Distal (>10kb) Multiome HiCAR | 790 | |
| chr14:60,655,802–60,657,953 | 624.2 kb | Distal (>10kb) Multiome HiCAR | 631 | |
| chr14:60,980,625–60,981,938 | 300.3 kb | Distal (>10kb) Multiome | 866 | |
| chr14:61,254,867–61,255,650 | 26.3 kb | Distal (>10kb) Multiome | 219 | |
| chr14:61,280,136–61,281,846 | 71 bp | At TSS Multiome | 391 | |
| chr14:61,286,297–61,286,456 | 4.8 kb | Proximal (<10kb) | 89 | |
| chr14:61,320,928–61,322,807 | 40.1 kb | Distal (>10kb) Multiome | 635 | |
| chr14:61,427,068–61,427,986 | 145.9 kb | Distal (>10kb) Multiome | 9 | |
| chr14:61,567,895–61,569,162 | 287.2 kb | Distal (>10kb) Multiome | 399 |
Genomic view of the TMEM30B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.