Enables aminophospholipid flippase activity and structural molecule activity. Involved in several processes, including phospholipid transport; positive regulation of transport; and xenobiotic transmembrane transport. Located in endoplasmic reticulum; endosome membrane; and plasma membrane. Part of phospholipid-translocating ATPase complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM30A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM30A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM30A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:73,653,023–73,654,818 | 1630.8 kb | Distal (>10kb) Multiome HiCAR | 944 | |
| chr6:75,204,283–75,209,417 | 78.7 kb | Distal (>10kb) Multiome | 741 | |
| chr6:75,243,188–75,244,541 | 41.0 kb | Distal (>10kb) Multiome | 858 | |
| chr6:75,282,626–75,282,992 | 1.8 kb | Proximal (<10kb) | 28 | |
| chr6:75,283,886–75,285,703 | 97 bp | At TSS Multiome | 948 | |
| chr6:75,334,164–75,335,181 | 50.0 kb | Distal (>10kb) Multiome | 265 | |
| chr6:75,348,793–75,350,207 | 64.7 kb | Distal (>10kb) Multiome | 378 | |
| chr6:75,396,170–75,397,131 | 111.8 kb | Distal (>10kb) Multiome | 169 |
Genomic view of the TMEM30A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.