Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM268. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM268 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM268, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:114,370,337–114,371,120 | 240.7 kb | Distal (>10kb) Multiome HiCAR | 151 | |
| chr9:114,387,530–114,388,416 | 223.2 kb | Distal (>10kb) Multiome | 315 | |
| chr9:114,397,621–114,398,973 | 212.9 kb | Distal (>10kb) Multiome | 744 | |
| chr9:114,405,604–114,406,064 | 205.5 kb | Distal (>10kb) Multiome HiCAR | 266 | |
| chr9:114,409,093–114,409,699 | 202.0 kb | Distal (>10kb) Multiome HiCAR | 85 | |
| chr9:114,504,150–114,506,064 | 105.7 kb | Distal (>10kb) Multiome | 672 | |
| chr9:114,583,376–114,584,037 | 27.6 kb | Distal (>10kb) Multiome | 117 | |
| chr9:114,587,169–114,588,239 | 23.6 kb | Distal (>10kb) Multiome | 922 | |
| chr9:114,610,961–114,612,019 | 223 bp | At TSS Multiome | 923 | |
| chr9:114,799,438–114,800,403 | 188.7 kb | Distal (>10kb) Multiome | 162 | |
| chr9:114,906,930–114,907,676 | 295.8 kb | Distal (>10kb) Multiome | 185 | |
| chr9:114,907,898–114,908,612 | 297.1 kb | Distal (>10kb) Multiome | 544 |
Genomic view of the TMEM268 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.