Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM243. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM243 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM243, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:86,964,698–86,966,215 | 255.4 kb | Distal (>10kb) Multiome | 164 | |
| chr7:87,058,811–87,060,346 | 160.8 kb | Distal (>10kb) Multiome | 675 | |
| chr7:87,128,891–87,130,142 | 91.2 kb | Distal (>10kb) Multiome | 290 | |
| chr7:87,151,812–87,153,325 | 68.0 kb | Distal (>10kb) Multiome | 1045 | |
| chr7:87,218,879–87,221,122 | 8 bp | At TSS Multiome | 908 | |
| chr7:87,344,909–87,346,229 | 125.0 kb | Distal (>10kb) Multiome | 838 | |
| chr7:87,464,851–87,465,792 | 244.9 kb | Distal (>10kb) Multiome | 440 | |
| chr7:87,506,649–87,507,949 | 286.9 kb | Distal (>10kb) Multiome | 153 |
Genomic view of the TMEM243 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.