Involved in mitochondrial proton-transporting ATP synthase complex assembly. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM242. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM242 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM242, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:157,158,471–157,159,835 | 164.5 kb | Distal (>10kb) Multiome | 152 | |
| chr6:157,235,403–157,237,021 | 87.7 kb | Distal (>10kb) Multiome | 380 | |
| chr6:157,274,253–157,275,484 | 48.6 kb | Distal (>10kb) Multiome | 761 | |
| chr6:157,304,187–157,305,043 | 18.8 kb | Distal (>10kb) Multiome | 74 | |
| chr6:157,379,723–157,382,345 | 56.6 kb | Distal (>10kb) Multiome | 926 | |
| chr6:157,533,250–157,533,761 | 210.1 kb | Distal (>10kb) Multiome | 237 | |
| chr6:157,552,274–157,553,166 | 229.1 kb | Distal (>10kb) Multiome | 219 |
Genomic view of the TMEM242 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.