The protein encoded by this gene is a tetraspanin protein that is thought to be involved in WNT signaling. Defects in this gene are a cause of Joubert syndrome-14. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Transcription factors with Perturb-seq knockdown data for TMEM237. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM237 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM237, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:201,450,975–201,452,588 | 191.0 kb | Distal (>10kb) Multiome | 1008 | |
| chr2:201,642,360–201,643,621 | 89 bp | At TSS Multiome | 884 | |
| chr2:201,780,355–201,781,686 | 138.3 kb | Distal (>10kb) Multiome | 963 | |
| chr2:201,787,334–201,788,076 | 145.0 kb | Distal (>10kb) Multiome | 227 | |
| chr2:201,858,878–201,859,345 | 216.4 kb | Distal (>10kb) Multiome | 246 | |
| chr2:201,860,619–201,861,352 | 218.2 kb | Distal (>10kb) Multiome | 253 | |
| chr2:201,866,586–201,867,010 | 224.2 kb | Distal (>10kb) Multiome | 139 | |
| chr2:201,906,909–201,907,931 | 264.7 kb | Distal (>10kb) Multiome | 255 | |
| chr2:201,929,476–201,930,044 | 287.2 kb | Distal (>10kb) Multiome | 78 | |
| chr2:201,932,304–201,933,049 | 290.0 kb | Distal (>10kb) Multiome | 131 |
Genomic view of the TMEM237 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.