Predicted to be involved in flagellated sperm motility and spermatid cytoplasm removal during spermiation of flagellated sperm. Predicted to act upstream of or within maintenance of protein complex location. Predicted to be located in membrane. Predicted to be active in outer dense fiber. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM232. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM232 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM232, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:110,533,847–110,535,524 | 203.8 kb | Distal (>10kb) Multiome | 148 | |
| chr5:110,535,777–110,537,016 | 202.4 kb | Distal (>10kb) Multiome | 208 | |
| chr5:110,726,240–110,727,348 | 12.3 kb | Distal (>10kb) Multiome | 287 | |
| chr5:110,738,135–110,739,635 | 196 bp | At TSS Multiome | 896 | |
| chr5:111,069,762–111,071,332 | 331.8 kb | Distal (>10kb) Multiome HiCAR | 267 | |
| chr5:111,072,593–111,073,857 | 334.3 kb | Distal (>10kb) Multiome HiCAR | 461 |
Genomic view of the TMEM232 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.