Predicted to be located in Golgi apparatus and nuclear envelope. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM209. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM209 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM209, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:129,914,750–129,915,367 | 290.3 kb | Distal (>10kb) Multiome | 82 | |
| chr7:129,948,898–129,950,017 | 256.2 kb | Distal (>10kb) Multiome | 747 | |
| chr7:129,952,295–129,953,395 | 252.4 kb | Distal (>10kb) Multiome | 834 | |
| chr7:130,069,977–130,071,012 | 135.0 kb | Distal (>10kb) Multiome | 873 | |
| chr7:130,140,676–130,141,967 | 63.8 kb | Distal (>10kb) Multiome | 371 | |
| chr7:130,204,919–130,205,826 | 51 bp | At TSS Multiome | 874 | |
| chr7:130,272,868–130,273,649 | 68.0 kb | Distal (>10kb) Multiome | 220 | |
| chr7:130,440,505–130,441,456 | 235.7 kb | Distal (>10kb) Multiome | 666 | |
| chr7:130,485,879–130,487,031 | 280.9 kb | Distal (>10kb) Multiome | 696 | |
| chr7:130,733,079–130,734,492 | 528.5 kb | Distal (>10kb) Multiome HiCAR | 383 |
Genomic view of the TMEM209 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.