Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM178B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM178B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM178B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:140,924,039–140,925,334 | 149.2 kb | Distal (>10kb) Multiome | 930 | |
| chr7:141,014,405–141,015,593 | 59.0 kb | Distal (>10kb) Multiome | 1023 | |
| chr7:141,071,165–141,071,881 | 2.6 kb | Proximal (<10kb) Multiome | 334 | |
| chr7:141,072,031–141,072,256 | 1.8 kb | Proximal (<10kb) | 88 | |
| chr7:141,072,522–141,074,991 | 393 bp | At TSS Multiome | 574 | |
| chr7:141,550,725–141,551,853 | 477.3 kb | Distal (>10kb) Multiome HiCAR | 899 |
Genomic view of the TMEM178B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.