Predicted to be involved in negative regulation of osteoclast differentiation and regulation of cytosolic calcium ion concentration. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM178A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM178A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM178A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:39,364,530–39,365,418 | 300.9 kb | Distal (>10kb) Multiome | 145 | |
| chr2:39,436,378–39,438,239 | 228.6 kb | Distal (>10kb) Multiome | 945 | |
| chr2:39,484,116–39,485,280 | 181.3 kb | Distal (>10kb) Multiome | 235 | |
| chr2:39,664,916–39,667,114 | 45 bp | At TSS Multiome | 409 | |
| chr2:39,743,146–39,744,007 | 77.7 kb | Distal (>10kb) Multiome | 129 | |
| chr2:39,778,784–39,779,822 | 113.3 kb | Distal (>10kb) Multiome | 957 |
Genomic view of the TMEM178A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.