Involved in several processes, including cellular response to UV; regulation of cellular response to stress; and response to retinoic acid. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM161A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM161A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM161A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:18,870,063–18,870,526 | 268.0 kb | Distal (>10kb) Multiome | 148 | |
| chr19:18,895,036–18,896,591 | 242.3 kb | Distal (>10kb) Multiome | 554 | |
| chr19:18,918,971–18,919,972 | 218.9 kb | Distal (>10kb) Multiome | 828 | |
| chr19:18,932,038–18,933,012 | 205.9 kb | Distal (>10kb) Multiome | 312 | |
| chr19:18,940,835–18,941,417 | 197.2 kb | Distal (>10kb) Multiome | 336 | |
| chr19:19,017,061–19,017,561 | 121.2 kb | Distal (>10kb) Multiome | 21 | |
| chr19:19,032,820–19,034,059 | 104.8 kb | Distal (>10kb) Multiome | 944 | |
| chr19:19,063,253–19,064,386 | 74.7 kb | Distal (>10kb) Multiome | 781 | |
| chr19:19,105,310–19,106,514 | 32.8 kb | Distal (>10kb) Multiome | 447 | |
| chr19:19,110,429–19,110,857 | 27.8 kb | Distal (>10kb) Multiome | 131 | |
| chr19:19,119,998–19,121,362 | 17.9 kb | Distal (>10kb) Multiome | 304 | |
| chr19:19,134,710–19,135,106 | 3.4 kb | Proximal (<10kb) | 262 | |
| chr19:19,138,171–19,138,698 | 1 bp | At TSS Multiome | 642 | |
| chr19:19,139,694–19,139,923 | 1.2 kb | Proximal (<10kb) | 282 | |
| chr19:19,146,098–19,146,322 | 7.6 kb | Proximal (<10kb) | 326 | |
| chr19:19,170,055–19,170,692 | 31.9 kb | Distal (>10kb) Multiome | 403 | |
| chr19:19,191,912–19,193,209 | 54.1 kb | Distal (>10kb) Multiome | 939 | |
| chr19:19,202,895–19,203,773 | 65.0 kb | Distal (>10kb) Multiome | 599 | |
| chr19:19,224,938–19,225,553 | 86.7 kb | Distal (>10kb) Multiome | 646 | |
| chr19:19,261,403–19,261,973 | 123.2 kb | Distal (>10kb) Multiome | 205 | |
| chr19:19,272,869–19,273,464 | 134.7 kb | Distal (>10kb) Multiome | 236 | |
| chr19:19,320,030–19,321,531 | 182.2 kb | Distal (>10kb) Multiome | 839 | |
| chr19:19,384,944–19,386,424 | 247.1 kb | Distal (>10kb) Multiome | 788 | |
| chr19:19,405,072–19,406,890 | 267.2 kb | Distal (>10kb) Multiome | 1014 |
Genomic view of the TMEM161A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.