Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM154. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM154 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM154, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:152,535,271–152,537,069 | 143.7 kb | Distal (>10kb) Multiome | 955 | |
| chr4:152,540,175–152,541,082 | 139.4 kb | Distal (>10kb) Multiome | 203 | |
| chr4:152,679,625–152,680,356 | 22 bp | At TSS Multiome | 414 | |
| chr4:152,689,572–152,690,081 | 9.6 kb | Proximal (<10kb) | 37 | |
| chr4:152,779,006–152,780,778 | 99.9 kb | Distal (>10kb) Multiome | 903 | |
| chr4:152,808,636–152,809,308 | 129.0 kb | Distal (>10kb) Multiome | 113 | |
| chr4:152,935,635–152,938,175 | 256.3 kb | Distal (>10kb) Multiome | 620 |
Genomic view of the TMEM154 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.