Predicted to be involved in G protein-coupled receptor signaling pathway and response to pheromone. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM145. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM145 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM145, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:42,075,557–42,076,657 | 237.3 kb | Distal (>10kb) Multiome | 846 | |
| chr19:42,095,735–42,096,278 | 217.4 kb | Distal (>10kb) Multiome | 107 | |
| chr19:42,132,949–42,133,545 | 180.1 kb | Distal (>10kb) Multiome | 447 | |
| chr19:42,176,787–42,177,398 | 136.2 kb | Distal (>10kb) Multiome | 381 | |
| chr19:42,216,521–42,218,719 | 95.7 kb | Distal (>10kb) Multiome | 841 | |
| chr19:42,219,693–42,220,678 | 93.1 kb | Distal (>10kb) Multiome | 735 | |
| chr19:42,241,985–42,243,820 | 70.4 kb | Distal (>10kb) Multiome | 891 | |
| chr19:42,244,086–42,245,258 | 68.5 kb | Distal (>10kb) Multiome | 768 | |
| chr19:42,253,030–42,256,178 | 58.1 kb | Distal (>10kb) Multiome | 900 | |
| chr19:42,267,812–42,269,463 | 44.5 kb | Distal (>10kb) Multiome | 887 | |
| chr19:42,279,620–42,280,909 | 33.3 kb | Distal (>10kb) Multiome | 818 | |
| chr19:42,283,173–42,285,280 | 29.4 kb | Distal (>10kb) Multiome | 739 | |
| chr19:42,301,842–42,303,114 | 10.7 kb | Distal (>10kb) Multiome | 858 | |
| chr19:42,313,206–42,313,892 | 120 bp | At TSS Multiome | 515 | |
| chr19:42,323,530–42,326,402 | 12.2 kb | Distal (>10kb) Multiome | 833 | |
| chr19:42,386,878–42,387,621 | 74.0 kb | Distal (>10kb) Multiome | 602 | |
| chr19:42,396,430–42,397,663 | 83.6 kb | Distal (>10kb) Multiome | 585 | |
| chr19:42,401,221–42,402,278 | 88.4 kb | Distal (>10kb) Multiome | 475 | |
| chr19:42,422,934–42,424,367 | 110.5 kb | Distal (>10kb) Multiome | 439 |
Genomic view of the TMEM145 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.