This gene encodes a transmembrane protein with four predicted transmembrane domains. The protein is associated with a subpopulation of vesicular organelles corresponding to early endosomal structures, with the Golgi, and with lysosomes, and may participate in protein trafficking between these structures. Mutations in this gene and several other genes cause pheochromocytomas. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2022]
Transcription factors with Perturb-seq knockdown data for TMEM127. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM127 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM127, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:96,116,133–96,117,547 | 149.1 kb | Distal (>10kb) Multiome | 470 | |
| chr2:96,138,522–96,139,006 | 127.2 kb | Distal (>10kb) Multiome | 255 | |
| chr2:96,144,225–96,145,701 | 120.7 kb | Distal (>10kb) Multiome HiCAR | 423 | |
| chr2:96,148,417–96,148,969 | 117.3 kb | Distal (>10kb) Multiome | 318 | |
| chr2:96,207,850–96,209,429 | 57.1 kb | Distal (>10kb) Multiome | 1022 | |
| chr2:96,260,550–96,261,017 | 5.0 kb | Proximal (<10kb) | 671 | |
| chr2:96,265,014–96,266,655 | 127 bp | At TSS Multiome | 992 | |
| chr2:96,305,302–96,305,947 | 39.6 kb | Distal (>10kb) Multiome | 918 | |
| chr2:96,321,245–96,322,149 | 55.9 kb | Distal (>10kb) Multiome | 640 | |
| chr2:96,325,023–96,325,881 | 59.4 kb | Distal (>10kb) Multiome | 443 | |
| chr2:96,335,437–96,336,197 | 69.9 kb | Distal (>10kb) Multiome | 847 | |
| chr2:96,507,900–96,508,563 | 242.2 kb | Distal (>10kb) Multiome | 466 | |
| chr2:96,509,253–96,509,998 | 243.7 kb | Distal (>10kb) Multiome | 525 | |
| chr2:96,531,989–96,532,491 | 266.3 kb | Distal (>10kb) Multiome | 500 | |
| chr2:96,536,180–96,538,128 | 270.7 kb | Distal (>10kb) Multiome | 684 | |
| chr2:96,538,413–96,539,012 | 272.8 kb | Distal (>10kb) Multiome | 371 | |
| chr2:96,554,285–96,554,861 | 288.6 kb | Distal (>10kb) Multiome | 435 |
Genomic view of the TMEM127 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.